منابع مشابه
Epigenetic regulation of cardiac myocyte differentiation†
Cardiac myocytes (CMs) proliferate robustly during fetal life but withdraw permanently from the cell cycle soon after birth and undergo terminal differentiation. This cell cycle exit is associated with the upregulation of a host of adult cardiac-specific genes. The vast majority of adult CMs (ACMs) do not reenter cell cycle even if subjected to mitogenic stimuli. The basis for this irreversible...
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Radiotherapy is a fundamental part of cancer treatment but its use is limited by the onset of late adverse effects in the normal tissue, especially radiation-induced fibrosis. Since the molecular causes for fibrosis are largely unknown, we analyse if epigenetic regulation might explain inter-individual differences in fibrosis risk. DNA methylation profiling of dermal fibroblasts obtained from b...
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35 Received October 10, 2012; accepted November 21, 2012. Published online December 12, 2012; doi: 10.1620/tjem.229.35. *Qi Zhao and Cheng-Yong Qin contributed equally to this work. Correspondence: Kai Wang, M.D., Ph.D., Department of Hepatology, Qilu Hospital of Shandong University and Institute of Hepatology, Shandong University, 107# Wenhuaxi Road, Jinan, Shangdong 250012, P.R. China. e-mail...
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A s deaths from acute myocardial infarction have declined dramatically over the past several decades, more and more patients survive with chronic myocardial ischemia. Hearts of most patients who survive acute myocardial infarction undergo remodeling. Hearts of most patients with sustained hyperten-sion, another common cardiovascular disease, also show some degree of remodeling. The heart consis...
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The study of epigenetics in plants has a long and rich history, from initial descriptions of non-Mendelian gene behaviors to seminal discoveries of chromatin-modifying proteins and RNAs that mediate gene silencing in most eukaryotes, including humans. Genetic screens in the model plant Arabidopsis have been particularly rewarding, identifying more than 130 epigenetic regulators thus far. The di...
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ژورنال
عنوان ژورنال: World Journal of Cardiology
سال: 2015
ISSN: 1949-8462
DOI: 10.4330/wjc.v7.i11.784